Resolving degeneracy in diffusion MRI biophysical model parameter estimation using double diffusion encoding
نویسندگان
چکیده
منابع مشابه
Parameter estimation using macroscopic diffusion MRI signal models.
Macroscopic models of the diffusion MRI (dMRI) signal can be helpful to understanding the relationship between the tissue microstructure and the dMRI signal. We study the least squares problem associated with estimating tissue parameters such as the cellular volume fraction, the residence times and the effective diffusion coefficients using a recently developed macroscopic model of the dMRI sig...
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Stejskal and Tanner's ingenious pulsed field gradient design from 1965 has made diffusion NMR and MRI the mainstay of most studies seeking to resolve microstructural information in porous systems in general and biological systems in particular. Methods extending beyond Stejskal and Tanner's design, such as double diffusion encoding (DDE) NMR and MRI, may provide novel quantifiable metrics that ...
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Parameter estimation problems of diffusion models are discussed. The problems of maximum likelihood estimation and model selections from continuous observations are illustrated through diffusion growth model which generalizes some classical ones.
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Diffusion magnetic resonance imaging (dMRI) is an imaging modality that probes the diffusion characteristics of a sample via the application of magnetic field gradient pulses. If the imaging voxel can be divided into different Gaussian diffusion compartments with inter-compartment exchange governed by linear kinetics, then the dMRI signal can be described by the Kärger model, which is a well-kn...
متن کاملMicrostructural parameter estimation in vivo using diffusion MRI and structured prior information.
PURPOSE Diffusion MRI has recently been used with detailed models to probe tissue microstructure. Much of this work has been performed ex vivo with powerful scanner hardware, to gain sensitivity to parameters such as axon radius. By contrast, performing microstructure imaging on clinical scanners is extremely challenging. METHODS We use an optimized dual spin-echo diffusion protocol, and a Ba...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2019
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.27714